Table 3 CpG sites with a differences in methylation of >5% between males and females in meta-analysis of 4,172 samples
From: Meta-analysis of human methylation data for evidence of sex-specific autosomal patterns
GENE | CHR | Target ID | Meta-analysis P value | Meta-analysis Ī beta | NCBI description of protein function | n studies consistent effect |
|---|---|---|---|---|---|---|
SLC9A2 | 2 | cg20050113 | <2.2e-16 | -0.09 | Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. | 36 |
DDX43 | 6 | cg08124399 | <2.2e-16 | -0.07 | ATP-dependent RNA helicase in the DEAD-box family. | 39 |
SPESP1 | 15 | cg09886641 | <2.2e-16 | -0.06 | Human alloantigen involved in sperm-egg binding and fusion. | 37 |
FIGNL1 | 7 | cg05072008 | <2.2e-16 | -0.06 | May regulate osteoblast proliferation and differentiation. | 36 |
CRISP2 | 6 | cg04595372 | <2.2e-16 | -0.06 | Also known as Testis-Specific Protein TPX-1. May regulate some ion channelsā activity and thereby regulate calcium fluxes during sperm capacitation. | 36 |
NUPL1 | 13 | cg08532057 | <2.2e-16 | -0.06 | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 30 |