Figure 7
Detected putative thiopeptides. A Gene cluster of thiomuracin (tpd) (Nonomuraea str. Bp3714-39) in comparison to putative thiopeptide gene clusters of C. cellulovorans 743B and P. acnes KPA171202; Numbers represent the locus tag for each gene within the genome sequence of each organism. B Comparison of precursor peptides of thiomuracin (TpdA) and putative precursor peptides of C. cellulovorans 753B and P. acnes KPA171202; Cleavage site of leader and core peptide in bold. C Introduction of the central nitrogen heterocycle (red) in series d thiopeptides. D Chemical structure of thiomuracin A.