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Table 4 Genes expressing significant diet-by-strain interactions within enriched biochemical pathways

From: The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice

Biochemical pathways

Genes within pathway

Plasminogen activating cascade

Serpinf2 (↓HFSm), PlgD(↓HFSm), Fga(↓HFSm)

p53 pathway

Igfbp3D (↑HFSm), E2f1 (↑HFSm), Ccng1(↑HFSm), Tnfrsf6(↑HFSm), Cdc2a(↑HFSm)

Angiogenesis

Src(↑HFLg), Ang(↓HFSm), Mapk4L(↑HFLg, ↓HFSm), Dok2FL(↑HFSm), LpxnMS,Ob(↑HFSm), PdgfaD(↑HFSm)

Blood coagulation

Serpinf2(↓HFSm), PlgD(↓HFSm), Fga(↓HFSm)

Integrin signalling pathway

Fn1(↑HFLg, ↓HFSm), Src(↑HFLg), RrasD(↑HFSm), Mapk4L(↑HFLg, ↓HFSm), Arl11FL(↑HFSm)

Androgen/estrogene/progesterone biosynthesis

Hsd3b4(↓HFLg), Hsd3b2(↓HFSm)

Ornithine degradation

Azi2(↓HFSm)

FAS signaling pathway

Capg(↑HFSm), Tnfrsf6(↑HFSm)

Methylmalonyl pathway

MceeMS,P(↑HFSm)

Xanthine and guanine salvage pathway

Hprt1(↑HFSm)

p53 pathway feedback loops 2

E2f1(↑HFSm), Ccng1(↑HFSm)

  1. Arrows indicate wether expression levels were higher or lower in high-fat fed individuals verses low-fat fed individuals. HFSm=High-fat fed SM/J, HFLg=High-fat fed LG/J. Genes with superscripts are located within and near previously identified QTLs for a number of traits.
  2. D Diabetes QTL, L Lipid QTL, FL Fatty Liver QTL, MS Metabolic Syndrome QTL, O Obesity QTL.