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Table 1 Assessment of the 3D localization of functional annotations in P. falciparum Ring stage

From: Distance-based assessment of the localization of functional annotations in 3D genome reconstructions

Functional annotation

MPED

Contact enrichment

 

q-values

q-values

Centromeres

6.0e-05

8.4e-05

Telomeres

6.0e-05

8.4e-05

VRSM (all)

6.0e-05

8.4e-05

VRSM (subtelomeric)

6.0e-05

8.4e-05

VRSM (internal)

1.6e-04

8.4e-05

rDNA genes

0.42

0.10

Cluster 1

0.73 ↓

0.17

Cluster 2

4.4e-02

0.70 ↓

Cluster 3

0.18

0.45 ↓

Cluster 4 (Ring)

6.0e-05

1.0e-02

Cluster 5 (Ring)

0.24

0.45 ↓

Cluster 6 (Ring

6.0e-05

0.70 ↓

Cluster 7 (Ring)

6.0e-05

0.39 ↓

Cluster 8

4.0e-02

0.86 ↓

Cluster 9

1.0e-02

0.39 ↓

Cluster 10

2.1e-03

0.81

Cluster 11

0.10

0.74 ↓

Cluster 12

9.2e-03

0.11 ↓

Cluster 13

6.5e-02

0.44 ↓

Cluster 14

0.11

0.70 ↓

Cluster 15

5.2e-02

0.81 ↓

  1. MPED: the median of pairwise Euclidean distances in the 3D reconstruction. Contact enrichment: enrichment of dichotomized “close” pairs in the Hi-C contact data. Bold indicates q-value <0.05. Down arrow indicates dispersion (otherwise co-localization). All functional annotations that were tested are included. “Cluster N” refers to genes with life cycle -regulated expression, which were clustered in (Le Roch et al [14]). Clusters that have high gene expression in the Ring stage are indicated in parentheses.