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Figure 2 | BMC Genomics

Figure 2

From: Characterization of age signatures of DNA methylation in normal and cancer tissues from multiple studies

Figure 2

DNA methylation correlation and age-associated CpG loci across individual studies. (A) Heat map representing the Pearson’s correlation coefficients between all samples of normal and cancer tissues used in this study. A hierarchical clustering was used. (B) Box plot representing the correlations between normal samples or between cancer samples. P-value was calculated using a Wilcoxon rank-sum test. (C) Examples of CpG loci (i.e., CG23854009 and CG0888479) hypermethylated with age in the GSE32393 study. (D) Examples of CpG loci (i.e., CG23124451 and CG25256723) hypomethylated with age in the GSE41037 study. R: correlation coefficient. (E) The number of significant age-associated CpG loci in normal or cancer tissues from individual studies. The number and color in each cell corresponds to the number of significant age-associated CpG loci and its significance in terms of a P-value, respectively. P-value: Z-test result using the random distribution of the 100 age-permutation tests. NA: not available.

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