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Figure 3 | BMC Genomics

Figure 3

From: Characterization of age signatures of DNA methylation in normal and cancer tissues from multiple studies

Figure 3

Comparison of age-associated CpG loci across different studies with different tissue types. (A) Box plots of average methylation values (y-axis) per CpG unit in normal and cancer tissues across individual studies (x-axis). (B) Box plots of average methylation values per sample unit in normal or cancer tissue across individual studies. P-values were calculated by Kruskal–Wallis tests. (C, D) We checked the degree of overlap of age-associated CpG loci between studies by calculating the number of common CpG loci. We performed 100 age-permutation tests with the samples of individual studies to verify the significance of the degree of overlap. Hierarchical clustering results using the degree of overlap of age-associated CpG loci between different studies with different tissue types in normal (C) and cancer (D). P-value: a Z-test result using the distribution of 10,000 random selections.

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