Figure 3

Prediction performance of the four methods for different types of mutations. Matthews correlation coefficient (MCC) of SEQ-NEIGHB, SEQ-FREQ, EASE, and EASE-AA is shown as a function of the secondary structure type of the mutated residue, accessible surface area of the mutated residue (threshold of 25% for an exposed residue), and magnitude of the stability change. These are unseen-protein independent test results.