Table 3 20 top-scoring associations between drug-resistance profiles and point mutations in the case study for 1398 partially sequenced M.tuberculosis strains.

Fluoroquinolones

Rv0006

gyrA

D94A/G/N/Y/H

Y

Y

129.754964792

Fluoroquinolones

Rv0006

gyrA

A90G/V

Y

Y

41.8967753922

Streptomycin

Rv0682

rpsL

K43R

Y

Y

31.005838239

Isoniazid

Rv1908c

katG

S315T/S/G/N/I/R

Y

Y

27.1918713598

Ethambutol

Rv3795

embB

Q497P/R/K/H

Y

Y

17.1681425414

Streptomycin

Rv0682

rpsL

K88T/R/Q/M

Y

Y

16.2806822989

Fluoroquinolones

Rv0005

gyrB

N538K/T/D/S

Y

Y

12.6368065275

Rifampicin

Rv0667

rpoB

H445P/D/R/Y/L/N/Q

Y

Y

12.627849397

Streptomycin

Rvnr01

rrs

A1401G

Y

N

9.60726487825

Pyrazinamide

Rv2043c

pncA

T135P/A

Y

N

9.35766011848

Streptomycin

Rvnr01

rrs

A514C

Y

Y

8.96892262877

Rifampicin

Rv0667

rpoB

D435Y/V/H/G/A/N

Y

Y

7.63431166207

Fluoroquinolones

Rv0006

gyrA

S91P

Y

Y

7.57935978224

Pyrazinamide

Rv2043c

pncA

T-11C/G

Y

Y

6.76727069266

Ethambutol

Rv3795

embB

G406S/D/A/C

Y

Y

6.32500852932

Fluoroquinolones

Rv0006

gyrA

D89G/N

N

N

6.26814578901

Pyrazinamide

Rv2043c

pncA

L120P/R

Y

N

6.11085770664

Streptomycin

Rvnr01

rrs

C517T

Y

Y

5.16411345885

Ethambutol

Rv3795

embB

D328Y/G/H

Y

N

5.07901609928

Pyrazinamide

Rv2043c

pncA

V139G/A/M/L

Y

Y

5.05727324518