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Figure 8 | BMC Genomics

Figure 8

From: MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity

Figure 8

A hypothetical model to explain the molecular mechanisms of RDX-induced neurological disorder and neurotoxicity. RDX could first up-regulate the expression of miR-71, miR-27ab, miR-98, and miR-135a, then reduce the expression of the gens POLE4, C5ORF13, SULF1 and ROCK2, and eventually induce neurotoxicity. Over-expression of miR-27ab, or reduction of the expression of unknown miRNAs by RDX, could up-regulate HMGCR expression to cause neurotoxicity too.

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