Figure 7

Impact of the Rev mRNA stability on the kinetics of the viral components synthesis in an activated cell. The curves are distinguished by the parameters values: curve 1 - k = 0.0009 min^-1, curve 2 - k = 0.0014 min^-1, curve 3 - k = 0.0015 min^-1, curve 4 - k = 0.0016 min^-1, k = $k_{degr,2kb\text{\_}RNA\text{\_}Rev\text{\_}yyy}$,$yyy\in \left\{nuc,cyt\right\}$. Simulations for the version of the model in which the Rev-dependent transport of 9 kb RNA and 4 kb RNA from the nucleus to the cytoplasm leads to the release of the RNA bound Rev proteins into the free cytoplasmic fraction. However, the interaction of Rev with 9 kb- and 4 kb RNAs in the cytoplasm does not take place. The simulations were performed with the model parameter values listed in Table 1.