Protein abundance profiles are assigned to the overexpression spot modules together with the leading functional context as obtained using gene set enrichment analysis. Spots are assigned by capital letters. So-called single spiked profiles accumulate in rare spots in the lower-right part of the map. Lists of leading proteins are given for each spot in the supplementary text (Additional file 2). The vertical axis of the profiles is scaled in units of differential abundance, ΔE, representing the mean binary detection level centralized with respect to the mean abundance in all samples at all times.