Figure 4

The variation of target protein quantities in different models of 1 In loop in response to variation of h _s , k _q and initial miRNA molecules numbers. The values of h _s coefficient defining the amount of TFs, at which the transcription rate of miRNA gene is half of its maximum value, were within 0 - 400 mol. interval, the translation rates k _q for TF were taken from 0 - 0.16sec⁻¹ interval, initial quantities of miRNA were changed as described in section. Left column - Stop model, central column - Target degradation model, right column - Dual degradation model. A - C: In all models the quantity of target protein increases as h _s rise. D: In the Stop model the largest number of target protein molecules is observed at intermediate values of the kq coefficient. E-F: In the Target and Dual degradation models kq increase leads to increase of target protein quantity. G and I: In both Stop and Dual degradation models the form of target protein profile changes from the bell-shaped to the U-shaped one as the initial number of miRNA molecules rises. H: In the Target degradation model all profiles show moderate dependence on the change of the initial number of miRNA molecules.