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Figure 6 | BMC Genomics

Figure 6

From: Dynamics of miRNA driven feed-forward loop depends upon miRNA action mechanisms

Figure 6

The variation of target protein quantities in different models of 2 C loop in response to variation of hp, h g , k rs and h s coefficients, and initial miRNA and TF quantities. Parameters h p , h g , k rs define the action of miRNA on target mRNA, h s is the dissociation coefficient. The miRNA and TF initial quantities were changed as described in section. Left column - Stop model, central column - Target degradation model, right column - Dual degradation model. A: In the Stop model the quantity of target protein increases as the value of h p increases from 0 to 240 molecules. B: In the Target degradation model the quantity of target protein increases as the value of h g increases from 0 to 240 molecules. C: The increase of the k rs coefficient value from 0 to 8 × 10−5 mol−1sec−1 results in the fall of the target protein quantity in the Dual degradation model. D - F: In all models the increase of h s from 0 to 400 leads to decrease in target protein quantities. textbfG - I: The dependence of target protein quantities on initial miRNA molecules number in the models. J - L: The patterns of dependence of target protein quantities on initial TF quantities in the models.

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