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Table 1 The ability of 1In loop to buffer TF noise under variation of parameters in all three models.

From: Dynamics of miRNA driven feed-forward loop depends upon miRNA action mechanisms

Parameter values Stop Model Degr. Model Dual Degr. Model
  ε ̄ n ε ̄ n ε ̄ n
h s = 1 h s = 100 h s = 200 h s = 400 - 0 . 66 - 0 . 8 4 - 0 . 8 4 - 0 . 66 0 0 0 0 - 0 . 6 7 - 0 . 6 8 - 0 . 71 - 0 . 76 0 0 0 0 - 0 . 66 - 0 . 69 - 0 . 74 - 0 . 75 0 0 0 0
k q = 0 . 02 k q = 0 . 04 k q = 0 . 08 k q = 0 . 16 - 0 . 80 - 0 . 84 - 0 . 92 - 0 . 97 0 0 0 0 - 0 . 48 - 0 . 71 - 0 . 88 - 0 . 96 0 0 0 0 - 0 . 50 - 0 . 74 - 0 . 91 - 0 . 97 0 0 0 0
k s = 0 . 01 k s = 0 . 25 k s = 0 . 50 k s = 0 . 75 - 0 . 70 - 0 . 8 9 - 0 . 84 - 0 . 80 0 0 0 0 - 0 . 71 - 0 . 72 - 0 . 70 - 0 . 70 0 0 0 0 - 0 . 70 - 0 . 72 - 0 . 75 - 0 . 74 0 0 0 0
h p ( h g ) = 30 ; k r s = 1 1 0 - 5 h p ( h g ) = 60 ; k r s = 2 1 0 - 5 h p ( h g ) = 120 ; k r s = 4 1 0 - 5 h p ( h g ) = 240 ; k r s = 8 1 0 - 5 - 0 . 78 - 0 . 83 - 0 . 9 0 - 0 . 82 0 0 0 0 - 0 . 68 - 0 . 70 - 0 . 73 - 0 . 73 0 0 0 0 - 0 . 73 - 0 . 74 - 0 . 76 - 0 . 77 0 0 0 0
  1. For each model and for each parameter value we present the average ε value (left column) and the number n of experiments with positive value of this coefficient (right column). The method for calculation of ε is described in section. Negative ε values mean that TF noise is dampen in a loop. The extremal ε values achieved at intermediate parameter values are shown in bold. The Wilcoxon Rank-Sum Test was used to test for significance of difference between the values of ε for adjacent parameter values. The differences which are statistically insignificant at the α = 0.05 level are placed in parentheses.