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Table 3 The ability of 1C loop to buffer TF noise under of parameters in all three models.

From: Dynamics of miRNA driven feed-forward loop depends upon miRNA action mechanisms

Parameter values Stop Model Degr. Model Dual Degr. Model
  ε ̄ n ε ̄ n ε ̄ n
h s = 1 h s = 100 h s = 200 h s = 400 - 0 . 62 - 0 . 47 - 0 . 27 - 0 . 21 0 5 23 20 - 0 . 47 - 0 . 47 - 0 . 45 - 0 . 40 0 0 0 7 - 0 . 49 - 0 . 46 - 0 . 42 - 0 . 42 0 0 0 1
k q = 0 . 02 k q = 0 . 04 k q = 0 . 08 k q = 0 . 16 - 0 . 37 - 0 . 24 - 0 . 35 - 0 . 33 5 24 14 17 - 0 . 60 - 0 . 45 - 0 . 33 - 0 . 29 0 0 10 12 - 0 . 63 - 0 . 44 - 0 . 34 - 0 . 25 0 0 13 23
k s = 0 . 01 k s = 0 . 25 k s = 0 . 50 k s = 0 . 75 - 0 . 48 - 0 . 37 - 0 . 27 - 0 . 24 0 12 23 22 - 0 . 50 - 0 . 45 - 0 . 45 - 0 . 45 0 2 0 0 - 0 . 48 - 0 . 44 - 0 . 42 - 0 . 43 0 0 0 1
h p ( h g ) = 30 ; k r s = 1 ⋅ 1 0 - 5 h p ( h g ) = 60 ; k r s = 2 ⋅ 1 0 - 5 h p ( h g ) = 120 ; k r s = 4 ⋅ 1 0 - 5 h p ( h g ) = 240 ; k r s = 8 ⋅ 1 0 - 5 - 0 . 28 - 0 . 29 - 0 . 35 - 0 . 41 22 20 13 2 - 0 . 46 - 0 . 46 - 0 . 44 - 0 . 44 0 0 1 0 - 0 . 45 - 0 . 42 - 0 . 39 - 0 . 40 0 0 2 5
  1. For each model and for each parameter value we present the average ε value (left column) and the number n of experiments with positive value of this coefficient (right column). The method for calculation of ε is described in section. Negative ε mean that TF noise is dampen in a loop. The extremal ε values achieved at intermediate parameter values are shown in bold. The Wilcoxon Rank-Sum Test was used to test for significance of difference between the ε values for adjacent parameter values. The differences which are statistically insignificant at the α=0.05 level are placed in parentheses.
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BMC Genomics

ISSN: 1471-2164

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