Dynamics of miRNA driven feed-forward loop depends upon miRNA action mechanisms

BMC Genomics

Table 4 The ability of 2C loop to buffer TF noise under of parameters in all three models.

Parameter values	Stop Model		Degr. Model		Dual Degr. Model
	$ε ̄$	n	$ε ̄$	n	$ε ̄$	n
$h s = 1 h s = 100 h s = 200 h s = 400$	$- 0.71 - 0.49 - 0 .09 - 0.30$	$00344$	$- 0.69 - 0.57 - 0.57 - 0.64$	$0000$	$- 0.70 - 0.63 - 0.57 - 0.59$	$0000$
$k q = 0.02 k q = 0.04 k q = 0.08 k q = 0.16$	$- 0.07 - 0.17 - 0.64 - 0.94$	$432600$	$- 0.38 - 0.57 - 0.75 - 0.94$	$0000$	$- 0.30 - 0.58 - 0.82 - 0.94$	$2000$
$k s = 0.01 k s = 0.25 k s = 0.50 k s = 0.75$	$- 0.69 - 0.43 - 0.13 0.05$	$003055$	$- 0.69 - 0.56 - 0.58 - 0.61$	$0000$	$- 0.69 - 0.63 - 0.59 - 0.55$	$0000$
$h p (h g) = 30; k r s = 1 ⋅ 1 0 - 5 h p (h g) = 60; k r s = 2 ⋅ 1 0 - 5 h p (h g) = 120; k r s = 4 ⋅ 1 0 - 5 h p (h g) = 240; k r s = 8 ⋅ 1 0 - 5$	$0.07 - 0.14 - 0.42 - 0.61$	$582600$	$- 0.64 - 0 . 57 - 0 . 56 - 0.64$	$0000$	$- 0.63 - 0.59 - 0.49 - 0.42$	$0000$

For each model and for each parameter value we present the average ε value (left column) and the number n of experiments with positive value of this coefficient (right column). The method for calculation of ε is described in section. Negative ε mean that TF noise is dampen in a loop. The extremal ε values achieved at intermediate parameter values are shown in bold. The Wilcoxon Rank-Sum Test was used to test for significance of difference between the values of ε for adjacent parameter values. The differences which are statistically insignificant at the α = 0.05 level are placed in parentheses.

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