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Table 4 The ability of 2C loop to buffer TF noise under of parameters in all three models.

From: Dynamics of miRNA driven feed-forward loop depends upon miRNA action mechanisms

Parameter values Stop Model Degr. Model Dual Degr. Model
  ε ̄ n ε ̄ n ε ̄ n
h s = 1 h s = 100 h s = 200 h s = 400 - 0 . 71 - 0 . 49 - 0 .09 - 0 . 30 0 0 34 4 - 0 . 69 - 0 . 57 - 0 . 57 - 0 . 64 0 0 0 0 - 0 . 70 - 0 . 63 - 0 . 57 - 0 . 59 0 0 0 0
k q = 0 . 02 k q = 0 . 04 k q = 0 . 08 k q = 0 . 16 - 0 . 07 - 0 . 17 - 0 . 64 - 0 . 94 43 26 0 0 - 0 . 38 - 0 . 57 - 0 . 75 - 0 . 94 0 0 0 0 - 0 . 30 - 0 . 58 - 0 . 82 - 0 . 94 2 0 0 0
k s = 0 . 01 k s = 0 . 25 k s = 0 . 50 k s = 0 . 75 - 0 . 69 - 0 . 43 - 0 . 13 0 . 05 0 0 30 55 - 0 . 69 - 0 . 56 - 0 . 58 - 0 . 61 0 0 0 0 - 0 . 69 - 0 . 63 - 0 . 59 - 0 . 55 0 0 0 0
h p ( h g ) = 30 ; k r s = 1 1 0 - 5 h p ( h g ) = 60 ; k r s = 2 1 0 - 5 h p ( h g ) = 120 ; k r s = 4 1 0 - 5 h p ( h g ) = 240 ; k r s = 8 1 0 - 5 0 . 07 - 0 . 14 - 0 . 42 - 0 . 61 58 26 0 0 - 0 . 64 - 0 . 5 7 - 0 . 5 6 - 0 . 64 0 0 0 0 - 0 . 63 - 0 . 59 - 0 . 49 - 0 . 42 0 0 0 0
  1. For each model and for each parameter value we present the average ε value (left column) and the number n of experiments with positive value of this coefficient (right column). The method for calculation of ε is described in section. Negative ε mean that TF noise is dampen in a loop. The extremal ε values achieved at intermediate parameter values are shown in bold. The Wilcoxon Rank-Sum Test was used to test for significance of difference between the values of ε for adjacent parameter values. The differences which are statistically insignificant at the α = 0.05 level are placed in parentheses.