The burden of private mutations of demographic models and empirical data. The burden of private mutations for the same demographic models and empirical data as in Figure 1, using the same colors. This quantity corresponds to the percentage out of all heterozygous sites in a newly sequenced genome that are novel after n genomes have already been sequenced. Results are presented for n = 100, n = 492, n = 1000, n = 4299 and n = 10000. The value of 492 and 4299 are dictated by the sample size of the NR and ESP dataset, respectively. For empirical data, mean percentage across individuals is presented, together with error bars that denote ± one standard error across SNVs, estimated via bootstrapping (Methods). Double-slashes around a value of 0 on the x-axis represent instances where data for that sample size is not available in the respective dataset. Note that the range above 5% on the y-axis is rescaled. The corresponding values in this figure are shown in Table 1.