Comparison of conservation scores and accessibility among disease, neutral, and PGx variants. In each box-and-whisker plot, the black lines denote medians, boxes with gray background cover from the first to third quantile, and notches connecting to the boxes with dashed lines cover close to 95% interval. (A) Disease variants show strongest conservation and fall within a narrow score range; PGx variants are less conservative and the scores disperse in a larger range but less broad than neutral variants do. (B) Accessibility is measured by the number of water molecules. Disease variants are the least accessible, and the accessibility distribution of PGx variants is more similar to that of disease variants than to neutral ones, which scatter in a significantly larger range.