Spread of three types of variant in the neutral-disease plane. Dashed lines constitute the prediction decision boundary among three types of variant in the neutral (x)-disease (y) plane. The intersections in both figures have a coordinate (1/3, 1/3). The decision boundary consists of three lines: y - x = 0, 1 - 2x - y = 0, and 1 - x - 2y = 0. (A) Distribution of three groups of variants based on structural data. (B) Distribution of three groups of variants based on sequence data.