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Table 2 Features showing different distribution among three groups of variant.

From: In silico comparative characterization of pharmacogenomic missense variants

Data set Feature Variant τ P-value
   Disease PGx Neutral   
Structure Conservation -0.474 0.000 0.209 -0.22 6.1 × 10-9
  ConsNG -0.316 -0.152 -0.021 -0.21 7.6 × 10-8
  NNG 10.0 9.4 8.3 0.18 4.8 × 10-6
  ACC 30.4 42.0 52.8 -0.17 1.2 × 10-5
Sequence Conservation -0.323 0.145 0.340 -0.23 7.4 × 10-25
  1. Abbreviations: Conservation, conservation at the variant position; ConsNG, average conservation of 3D neighbors; NNG, number of 3D neighbors; ACC, accessibility in number of water molecules; τ, Kendall correlation coefficient. P-value is computed from Kendall correlation coefficient test. The Kendall test has been performed sorting the feature vector according their average values in each class (Disease, PGx and Neutral).