In silico comparative characterization of pharmacogenomic missense variants

BMC Genomics

Table 2 Features showing different distribution among three groups of variant.

Data set	Feature	Variant			τ	P-value
		Disease	PGx	Neutral
Structure	Conservation	-0.474	0.000	0.209	-0.22	6.1 × 10^-9
	ConsNG	-0.316	-0.152	-0.021	-0.21	7.6 × 10^-8
	NNG	10.0	9.4	8.3	0.18	4.8 × 10^-6
	ACC	30.4	42.0	52.8	-0.17	1.2 × 10^-5
Sequence	Conservation	-0.323	0.145	0.340	-0.23	7.4 × 10^-25

Abbreviations: Conservation, conservation at the variant position; ConsNG, average conservation of 3D neighbors; NNG, number of 3D neighbors; ACC, accessibility in number of water molecules; τ, Kendall correlation coefficient. P-value is computed from Kendall correlation coefficient test. The Kendall test has been performed sorting the feature vector according their average values in each class (Disease, PGx and Neutral).

ISSN: 1471-2164