Table 1 Overlap between GWAS reported genes and drug targets
From: GWAS and drug targets
Disease | Number of Drugs | GWAS reported genes | Number of drug targets | GWAS overlap, same disease* | GWAS overlap, all diseases** |
|---|---|---|---|---|---|
Acute lymphoblastic leukemia | 6 | 19 | 10 | 0 | 3 |
Age-related macular degeneration | 9 | 23 | 2 | 1 | 2 |
Allergic rhinitis | 69 | 11 | 20 | 0 | 5 |
Alzheimer's disease | 5 | 54 | 179 | 0 | 40 |
Amyotrophic lateral sclerosis | 3 | 26 | 2 | 0 | 1 |
Ankylosing spondylitis | 39 | 17 | 29 | 0 | 9 |
Arthritis | 168 | 7 | 112 | 0 | 35 |
Asthma | 102 | 43 | 52 | 1 | 19 |
Atopic dermatitis | 12 | 8 | 3 | 0 | 1 |
Atrial fibrillation | 45 | 7 | 25 | 0 | 14 |
Attention deficit hyperactivity disorder | 3 | 81 | 1 | 0 | 1 |
Autism | 3 | 6 | 10 | 0 | 5 |
Basal cell carcinoma | 6 | 8 | 9 | 0 | 2 |
Bipolar disorder/Schizophrenia | 93 | 215 | 110 | 1 | 32 |
Blood pressure/Hypertension | 351 | 100 | 114 | 3 | 35 |
Breast cancer | 84 | 42 | 43 | 1 | 13 |
Celiac disease | 3 | 74 | 1 | 0 | 0 |
Chronic kidney disease | 8 | 69 | 6 | 0 | 2 |
Chronic lymphocytic leukemia | 14 | 17 | 29 | 0 | 5 |
Chronic myeloid leukemia | 6 | 9 | 15 | 0 | 6 |
Chronic obstructive pulmonary disease | 14 | 18 | 7 | 0 | 2 |
Colorectal cancer | 8 | 14 | 16 | 0 | 6 |
Coronary heart disease | 6 | 84 | 5 | 0 | 3 |
Crohn's disease | 7 | 136 | 23 | 0 | 9 |
Cystic fibrosis | 8 | 7 | 11 | 0 | 5 |
Depression/Depressive disorder | 45 | 68 | 73 | 0 | 17 |
Diabetes | 46 | 205 | 59 | 4 | 21 |
Duodenal ulcer | 8 | 2 | 18 | 0 | 5 |
Emphysema | 10 | 5 | 17 | 0 | 5 |
Endometrial cancer | 1 | 2 | 2 | 0 | 0 |
Endometriosis | 5 | 4 | 7 | 0 | 3 |
End-stage renal disease | 2 | 2 | 8 | 0 | 3 |
Epilepsy | 18 | 1 | 53 | 0 | 10 |
Esophageal cancer | 1 | 18 | 2 | 0 | 1 |
Gallstones | 1 | 1 | 1 | 0 | 0 |
Gastric cancer | 2 | 3 | 1 | 0 | 0 |
Glaucoma | 24 | 13 | 31 | 0 | 6 |
Glioblastoma | 2 | 1 | 1 | 0 | 0 |
Heart failure | 51 | 16 | 65 | 0 | 27 |
HIV/AIDS | 54 | 62 | 53 | 1 | 9 |
Hodgkin's lymphoma | 8 | 7 | 31 | 0 | 7 |
Hypertriglyceridemia | 2 | 5 | 4 | 0 | 3 |
Hypothyroidism | 5 | 43 | 8 | 1 | 5 |
Inflammatory bowel disease | 2 | 18 | 8 | 0 | 4 |
Kawasaki disease | 1 | 20 | 11 | 1 | 5 |
Malaria | 17 | 3 | 17 | 0 | 4 |
Male infertility | 6 | 5 | 3 | 0 | 3 |
Melanoma | 9 | 20 | 6 | 0 | 0 |
Menopause age | 9 | 23 | 15 | 0 | 4 |
Migraine | 20 | 7 | 46 | 0 | 10 |
Multiple myeloma | 7 | 3 | 10 | 0 | 3 |
Multiple sclerosis | 10 | 123 | 30 | 1 | 12 |
Myocardial infarction | 29 | 14 | 44 | 0 | 17 |
Narcolepsy | 2 | 4 | 6 | 0 | 1 |
Nephropathy/Nephrotic syndrome | 20 | 26 | 38 | 0 | 9 |
Neuroblastoma | 2 | 2 | 6 | 0 | 2 |
Non-small cell lung cancer | 5 | 7 | 10 | 0 | 1 |
Obesity | 4 | 40 | 11 | 0 | 4 |
Osteoarthritis | 26 | 3 | 46 | 0 | 10 |
Osteoporosis | 13 | 10 | 10 | 0 | 2 |
Ovarian cancer | 5 | 10 | 4 | 0 | 1 |
Paget's disease | 4 | 9 | 6 | 0 | 1 |
Pancreatic cancer | 2 | 29 | 11 | 0 | 4 |
Panic disorder | 6 | 10 | 18 | 0 | 4 |
Parkinson's disease | 20 | 62 | 184 | 1 | 34 |
Polycystic ovary syndrome | 2 | 7 | 2 | 0 | 1 |
Prostate cancer | 14 | 94 | 21 | 0 | 8 |
Psoriasis/Psoriatic arthritis | 19 | 30 | 39 | 0 | 13 |
Refractive error | 1 | 4 | 4 | 0 | 1 |
Restless legs syndrome | 2 | 6 | 18 | 0 | 6 |
Rheumatoid arthritis | 46 | 67 | 80 | 2 | 29 |
Sleepiness | 1 | 2 | 2 | 0 | 0 |
Stevens-Johnson syndrome/toxic epidermal necrolysis | 1 | 12 | 1 | 0 | 0 |
Stroke | 8 | 4 | 7 | 0 | 6 |
Tardive dyskinesia | 3 | 1 | 22 | 0 | 7 |
Testicular cancer | 4 | 7 | 6 | 0 | 2 |
Thyroid cancer | 2 | 5 | 3 | 0 | 2 |
Tuberculosis | 12 | 5 | 18 | 0 | 4 |
Type 1 diabetes | 8 | 74 | 18 | 0 | 8 |
Type 2 diabetes | 28 | 91 | 34 | 3 | 13 |
Ulcerative colitis | 5 | 95 | 9 | 1 | 6 |
Uterine fibroids | 1 | 7 | 1 | 0 | 0 |
Venous thromboembolism | 1 | 7 | 3 | 0 | 2 |
Vitiligo | 4 | 25 | 8 | 1 | 2 |
Mean | 19.90 | 29.18 | 24.00 | 0.26 | 7.09 |