Figure 1

Clonal expansions arise as asexual growth from a single clone. Left: Phylogenetic algorithms compare the descendant clones across their genomes to reconstruct the evolutionary history. We, however, measure population diversity across the segregating sites, via summing their frequency, to estimate evolutionary properties. Right: The estimates for the simulated datasets. Estimates based on MAF represent the lower bound of those based on D _T . The mean evolutionary rate, $〈{\overline{\mu }}_i〉$, is given in 10^-4 substitutions/site per time point. The standard errors are derived from 95% confidence intervals via 1,000 simulated datasets.