Figure 2

Overview of different computational steps employed in the identification of putative essential targets (non-host homologous and host homologous) for drugs and vaccines from the core-proteome of 15 C . pseudotuberculosis strains. Figure 2b. Intra-species subtractive modelomics workflow for conserved targets identification in C. pseudo tuberculosis species. The table (from left to right) represents the total number of protein sequences as an input data in fasta format fed to the MHOLline workflow (upper forward arrow). The remaining columns show the output data of group G2 (upper backward arrow), first by BATS and then by Filter tools of the MHOLline workflow respectively. Columns 4^th-7^th constitute the number of protein sequences of different qualities of all 15 Cp strains, where the sequences of 14 Cp strains were compared using BLASTp, to the sequences of Cp1002 strain as reference, for the identification of conserved protein targets (core-modelome). The funnel shows how this workflow processes and filters a large quantity of genomic data for putative drug and vaccine targets identification of a pathogen.