Table 2 Drug and/or vaccine targets prioritization parameters and functional annotation of the four essential non-host homologous putative targets.
Gene and protein codes | Official full name | Number of cavities with Drug Scorea > 0.80 | Number of cavities with Drug Scorea > 0.60 and < 0.80 | Mol. Wt (KDa)b | Functionsc | Cellular componentd | Pathwayse | Virulencef |
|---|---|---|---|---|---|---|---|---|
Cp1002_0515 MtrA | DNA-binding response regulator mtrA | 1 | 2 | 25.97 | MF: DNA binding, two-component response regulator activity. BP: Intracellular signal transduction, regulation of transcription, DNA-dependent | Intracellular/ Cytoplasm | Two-component signaling systems | Yes |
Cp1002_0742 IspH | 4-hydroxy-3-methylbut-2-enyl diphosphatereductase | 1 | 4 | 36.59 | MF: Metal ion binding, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity, 3 iron, 4 sulfur cluster binding EC: 1.17.1.2 BP: Dimethylallyldiphosphate biosynthetic process, isopentenyldiphosphate biosynthetic process, mevalonate-independent pathway | Cytoplasm | Inositol phosphate metabolism/ Pentose phosphate pathway/Terpene metabolism | Yes |
Cp1002_1648 TcsR | Two-component system transcriptional regulatory protein | 3 | 2 | 21.93 | MF: Sequence-specific DNA binding, two-component response regulator activity, sequence-specific DNA binding transcription factor activity BP: Intracellular signal transduction, transcription, DNA-dependent | Intracellular/ Cytoplasm | Two-component system | Yes |
Cp1002_1676 Nrdl | Ribonucleoside-diphosphatereductase alpha chain | 1 | 1 | 88.02 | MF: ATP binding, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor BP: DNA replication | Cytoplasm | Pyrimidine metabolism/ Purine metabolism | Yes |