Figure 1
From: Modelling the onset of senescence at the G1/S cell cycle checkpoint
Regulatory network of cell-fate decision upon DNA damage involving (A) the G1/S checkpoint arrest network and (B) the senescence regulatory pathway. Rectangular nodes indicate Boolean components, whereas ellipses represent multi-valued components; green arrows represent activations and red bar arrows inhibitions. Input nodes (dark grey ellipses) SSB and DSB stand for single and double DNA-strand breaks respectively. Output nodes (white rectangles) correspond to the four different outcomes (cell fates). Internal nodes embody the main regulators of the fate decision.