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Table 3 Accuracy, sensitivity, PPV and F-Score in % for Ion Torrent dataset and fold change threshold f of 1, 1.5, and 2.

From: Bootstrap-based differential gene expression analysis for RNA-Seq data with and without replicates

Fold Change

Method

Accuracy %

Sensitivity %

PPV %

F-Score %

 

FisherTotal

71.68%

72.76%

90.56%

80.69%

 

FisherHousekeeping

67.15%

66.87%

94.74%

78.40%

 

FisherERCC

71.39%

72.45%

88.97%

79.86%

1

GFOLD

75.77%

77.55%

90.43%

83.50%

 

IsoDE-Match

81.75%

86.38%

82.18%

84.05%

 

IsoDE-All

81.46%

86.07%

82.13%

84.05%

 

FisherTotal

74.16%

78.39%

85.06%

81.59%

 

FisherHousekeeping

76.06%

73.23%

92.96%

81.93%

 

FisherERCC

74.31%

78.59%

85.45%

81.87%

1.5

GFOLD

75.47%

77.63%

87.88%

82.44%

 

IsoDE-Match

77.66%

83.94%

84.75%

84.34%

 

IsoDE-All

77.81%

84.13%

84.45%

84.29%

 

FisherTotal

79.71%

83.02%

84.00%

83.51%

 

FisherHousekeeping

81.75%

80.70%

88.75%

84.53%

 

FisherERCC

79.42%

82.56%

84.12%

83.33%

2

GFOLD

80.58%

76.74%

90.66%

83.12%

 

IsoDE-Match

81.75%

85.81%

84.63%

85.22%

 

IsoDE-All

81.61%

86.28%

84.13%

85.19%

  1. The number of bootstrap samples is M = 200 for IsoDE-Match and M = 20 for IsoDE-All, and bootstrap support was determined using the binomial model with significance level α = 0.05.