Figure 4

Patterns of binding and CNV in the five groups of cell-type specific regions identified by dCaP. (A) The five heatmaps represent the five groups of cell-type specific regions identified by dCaP. Each heatmap corresponds to one specific cell-type. Each row in a heatmap shows a cell-type specific region and each column shows the relative binding signals from one of the 15 data tracks. The first three columns are the relative binding signals of the three factors (CTCF, DHS and POL2) in the GM12878 cell lines. The remaining columns are ordered in the same way for HUVEC, HeLa-S3, HepG2 and K562 cell lines, respectively. The rows are first ordered by their clustering class (enriched/depleted) and within each class, the cell-type specific regions are ordered by their genomic locations. (B) Heatmap of CNVs in the five groups of cell-type specific regions. The rows of the heatmap are arranged in the same way as in A and the columns show different types of CNVs in order of GM12878, HUVEC, HeLa-S3, HepG2 and K562. (C) Scatter plots of K-means clustering on the relative binding signals of the three factors in each group of cell-type specific regions.