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Table 5 Information on genes that have significantly many putative G4 structures.

From: Using hidden Markov models to investigate G-quadruplex motifs in genomic sequences

Gene symbol

Length (nt)

Gene ontology

HTF9C

5371

Function: RNA binding, methyltransferase activity, nucleotide binding.

Process: metabolic process.

TRAF

22332

Function: ligase activity, metal ion binding, protein binding, ubiquitin-protein, ligase activity, zinc ion binding.

Process: activation of MAPKKK activity, positive regulation of MAPKKK cascade, protein ubiquitination, regulation of apoptosis, regulation of transcription, DNA-dependent, transcription.

Component: ubiquitin ligase complex.

NGFRAP1

1734

Function: metal ion binding, molecular function.

Process: apoptosis, biological_process, multicellular organismal development.

Component: cellular_component, nucleus.

IMPDH1

17976

Function: IMP dehydrogenase activity, catalytic activity, metal ion binding, oxydoreductase activity, potassium ion binding.

Process: GMP biosynthetic process, GTP biosynthetic process, lymphocyte proliferation, metabolic process, purine nucleotide biosynthetic process, response to stimulus, visual perception.

  1. Note that in the gene ontology column, the words "molecular_function," "biological_process" and "cellular_component" are used to show that details are unclear.