Skip to main content

Table 1 Cancer disease association with genes selected in the present study based on Gendoo server.

From: TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer

Gene Symbol

RefSeq mRNA

Cancer associations

(P-value)

  

PC2 vs PC2

SLC22A3

NM_021977

Gonadoblastoma (0.0002), Dysgerminoma (0.00075), Testicular Neoplasms (0.00456), Ovarian Neoplasms (0.0297), Cell Transformation, Neoplastic (0.0384)

DFNA5

NM_004403

Melanoma (0.006),

SPG20

NM_015087

Hepatoblastoma (0.0033), Liver Neoplasms (0.00496)

CYP1B1

NM_000104

Breast Neoplasms (1.13 × 10-45), Endometrial Neoplasms (2.44 × 10-12), Lung Neoplasms (1.56 × 10-9), Prostatic Neoplasms (4.65e-9), Adenocarcinoma (6.03 × 10-6), Ovarian Neoplasms (1.35 × 10-5) Carcinoma, Squamous Cell (0.00018), Colorectal Neoplasms (0.000337), Head and Neck Neoplasms (0.00052), Adenoma, Liver Cell (0.0072), Urinary Bladder Neoplasms (0.012), Neoplasms (0.019), Carcinoma, Small Cell (0.028), Carcinoma, Non-Small-Cell Lung (0.0326)

ALX1

NM_006982

Carcinoma (0.000305), Chondrosarcoma (0.00129), Bone Neoplasms (0.0106), Uterine Cervical Neoplasms (0.011)

TFPI2

NM006528

Uterine Neoplasms (2.6 × 10-21), Neoplasm Invasiveness (1.18 × 10-14), Choriocarcinoma (2.33 × 10-13), Fibrosarcoma (7.98 × 10-9), Glioma (2.50 × 10-8), Cystadenocarcinoma (1.68 × 10-5), Lung Neoplasms (6.74 × 10-5), Carcinoma, Non-Small-Cell Lung (0.00559)

HOXA9

NM_152739

Leukemia, Myeloid (2.0 × 10-48), Leukemia, Myeloid, Acute (9.24 × 10-30), Cell Transformation, Neoplastic (4.64 × 10-29), Leukemia (9.46 × 10-19), Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2.64 × 10-14), Precursor Cell Lymphoblastic Leukemia-Lymphoma (2.46 × 10-8), Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (1.65 × 10-6), Myoma (0.00046), Leukemia, T-Cell (0.0012), Endodermal Sinus Tumor (0.0079), Seminoma (0.0157),

HOXA11

NM_005523

Uterine Neoplasms (8.23 × 10-7), Choriocarcinoma (3.97 × 10-5), Carcinoma, Endometrioid (0.0065), Adenocarcinoma, Clear Cell (0.00662), Wilms Tumor (0.0076),

PCSK1

NM000439

Bronchial Neoplasms (0.0022), Adenoma (0.0030), Adenoma, Islet Cell (0.0035), Bile Duct Neoplasms (0.011)

SPARC

NM_003118

Neoplasm Invasiveness (8.42 × 10-14), Glioma (1.35 × 10-8), Brain Neoplasms (1.01 × 10-7), Melanoma (2.99 × 10-7), Lung Neoplasms (1.43 × 10-5), Carcinoma (0.00013), Carcinoma, Non-Small-Cell Lung (0.0009)

  

PC3 vs PC3

HOXB2

NM_002145

Lung Neoplasms (0.000159), Leukemia, Myeloid (0.000326), Pulmonary Emphysema (0.00139), Carcinoma, Embryonal (0.0025), Adenocarcinoma (0.0054), Leukemia, Erythroblastic, Acute (0.0096), Leukemia, Promyelocytic, Acute (0.0124), Carcinoma, Small Cell (0.0148), Carcinoma, Non-Small-Cell Lung (0.0387)

CCDC8

NM_032040

 

ZNF114

NM_153608

 

DIO2

NM_000793

Choriocarcinoma (0.000616), Carcinoma, Papillary (0.00366), Hemangioma (0.0099), Adenoma (0.019), Neuroblastoma (0.025)

LAPTM5

NM_006762

Carcinoma, Hepatocellular (0.000396), Liver Neoplasms (0.000495), Multiple Myeloma (0.00947), Neoplasm Recurrence (0.010), Cell Transformation, Neoplastic (0.032)

RGS1

NM_002922

Burkitt Lymphoma (3.55 × 10-5), Lymphoma, B-Cell (9.14 × 10-5), Leukemia-Lymphoma, Adult T-Cell (0.0076), Lymphatic Metastasis (0.0329), Skin Neoplasms (0.0364), Stomach Neoplasms (0.0454), Melanoma (0.0455)

B3GALNT1

NM_003781

Neuroblastoma (0.0034)

  

PC5 vs PC4

TINAGL1

NM_022164

Carcinoma, Hepatocellular (0.000119), Neoplasms (0.0295)

PMEPA1

NM_020182

Prostatic Neoplasms (2.30e-12), Carcinoma, Renal Cell (0.0233), Kidney Neoplasms (0.032)

CX3CL1

NM_002996

Neuroblastoma (0.0014)

ICAM1

NM_000201

Melanoma (0.00305), astrocytoma (0.00644), Granular Cell Tumor (0.0166), Colonic Neoplasms (0.0233), Lymphoma, AIDS-Related (0.023), Adenoma, Oxyphilic (0.0433)