Figure 8

Signaling pathway of coagulation cascade for schizophrenia. This figure illustrates the signaling pathway of coagulation process for schizophrenia. The modulation of G-protein couple receptor on the cell membrane involved the existence of A(2A)-NCS-1 complex by neuronal calcium binding protein, NSC-1 and Adenosine A2a receptor. The tissue factor triggered by antipsychotic-associated DRD2/3 receptor was released into vessel lumen to activate the cascade(F3, F7 and F10) of extrinsic pathway of coagulation process. In cluster 39, NCS-1 gene is associated with inhibition of dopamine D2 desensitization, and its expression was decreased in schizophrenic patients. The under-expressed genes in cluster 39 might contribute to the potential pathogenesis of schizophrenia.