Figure 4
From: Homopharma: A new concept for exploring the molecular binding mechanisms and drug repurposing
The pharma-interface and Homopharma groups of serine/threonine-protein kinase Pim-1 and quercetin complex. (A) The pharma-interface of serine/threonine-protein kinase Pim-1 (PIM1) and quercetin complex consists of four pharma-motifs. The protein-compound interactions are grouped into six Homopharma groups. (B) The superimposed structures of Homopharma 3 and conserved interacting residues (residue numbering of PDB code: 3BV2). (C) The superimposed structures of Homopharma 4 and conserved interacting residues (residue numbering of PDB code: 3GUB).