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Table 4 Performance of MHC2MIL(fl) compared to MHC2MIL(fl+kp). For each allele, the largest value is displayed in boldface.

From: MHC2MIL: a novel multiple instance learning based method for MHC-II peptide binding prediction by considering peptide flanking region and residue positions

allele

MHC2MIL(fl)

MHC2MIL(fl+kp)

HLA-DPA1_01-DPB1_0401

0.778

0.791

HLA-DPA1_0103-DPB1_0201

0.790

0.808

HLA-DPA1_0201-DPB1_0101

0.817

0.834

HLA-DPA1_0201-DPB1_0501

0.791

0.805

HLA-DPA1_0301-DPB1_0402

0.832

0.846

HLA-DPB1_0301-DPB1_0401

0.791

0.790

HLA-DQA1_0101-DQB1_0501

0.768

0.781

HLA-DQA1_0102-DQB1_0602

0.763

0.769

HLA-DQA1_0301-DQB1_0302

0.672

0.706

HLA-DQA1_0401-DQB1_0402

0.737

0.774

HLA-DQA1_0501-DQB1_0201

0.779

0.810

HLA-DQA1_0501-DQB1_0301

0.809

0.817

HLA-DRB1_0101

0.786

0.787

HLA-DRB1_0301

0.808

0.803

HLA-DRB1_0401

0.741

0.732

HLA-DRB1_0404

0.791

0.782

HLA-DRB1_0405

0.792

0.785

HLA-DRB1_0701

0.819

0.823

HLA-DRB1_0802

0.712

0.716

HLA-DRB1_0901

0.733

0.735

HLA-DRB1_1101

0.834

0.838

HLA-DRB1_1302

0.745

0.734

HLA-DRB1_1501

0.765

0.763

HLA-DRB3_0101

0.756

0.757

HLA-DRB4_0101

0.787

0.792

HLA-DRB5_0101

0.803

0.808

average AUC

0.777

0.784

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BMC Genomics

ISSN: 1471-2164

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