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Table 2 Example 2 - estimation results

From: Mixture SNPs effect on phenotype in genome-wide association studies

  

Simulation Case 1

 

Simulation Case 2

Parameters

      
 

True value

Estimates from

Estimates from

True value

Estimates from

Estimates from

  

HBM (s.e)a

MLM (s.e)a

 

HBM (s.e)a

MLM (s.e)a

0

0.12 (0.08)

0.12 (0.13)

0

0.09 (0.09)

0.12 (0.07)

0.1

0.13 (0.01)

0.005 (0.002)

0.1

0.13 (0.05)

0.009 (0.002)

3

2.86 (1.05)

3.15 (1.45)

3

3.67 (1.13)

3.18 (1.05)

3

2.37 (1.34)

2.53 (2.01)

3

3.17 (2.13)

8.1 (3.25)

0.003

0.0024 (0.001)

-

0.003

0.0025 (0.001)

-

PVE

0.5

0.45 (0.24)

0.44 (0.23)

0.5

0.46 (0.25)

0.72 (0.33) b

Number of Random Effects

100,000

 
  1. aValues in the parenthesis are standard errors. bThe PVE estimated by MLM is higher than the true values in both simulation cases.