Mixture SNPs effect on phenotype in genome-wide association studies

Wang, Ling; Shen, Haipeng; Liu, Hexuan; Guo, Guang

doi:10.1186/1471-2164-16-3

BMC Genomics

Table 5 Per allele change in BMI for association SNPs identified by HBM

From: Mixture SNPs effect on phenotype in genome-wide association studies

The Framingham heart study
Gene^a	SNPs^b	Per allele change	Per allele change	Gene^a	SNPs^b	Per allele change	Per allele change
		in BMI by HBM	in BMI by MLM			in BMI by HBM	in BMI by MLM
CDH13	rs4508407	0.249	0.009	NAA60	rs12448488	0.209	0.013
CMIP	rs2966097	0.187	0.011	PRMT7	rs3785114	0.201	0.006
FTO	rs9939609	0.149	0.01	RABEP2	rs7184597	0.016	0.006
FTO	rs9939973	0.224	0.014	SDR42E1	rs11443	0.204	0.011
RBFOX1	rs11641750	0.225	0.012	SHISA9	rs149917	0.228	0.009
RBFOX1	rs17137899	0.245	0.01	WDR59	rs4888320	0.105	0.012
RBFOX1	rs17140501	0.039	0	ZNF423	rs4785325	0.214	0.014
SLC38A8	rs12716746	0.128	0.007		rs11860830	0.252	0.008
SLC38A8	rs4782578	0.167	0.009		rs12325385	0.201	0.009
WWOX	rs17711186	0.197	0.013		rs12447727	0.108	0.011
ATP2C2	rs962877	0.05	0.003		rs1318275	0.06	0
CACNG3	rs11648890	0.075	0.007		rs16947390	0.064	0.005
CENPN	rs1048194	0.082	0.002		rs17503512	0.004	0.001
CKLF-CMTM1	rs896086	0.099	0.01		rs2626640	0.148	0.007
KLHDC4	rs4843689	0.23	0.008		rs2631530	0.264	0.011
LOC101927676	rs1103775	0.17	0.009		rs30121	0.161	0.001
LOC101927998	rs328345	0.057	0.007		rs4784621	0.023	0.001
LOC102723396	rs4399544	0.078	0.008		rs7201071	0.109	0.009
MEFV	rs11466045	0.157	0.011		rs7202145	0.029	0.001
MGRN1	rs841224	0.094	0.008		rs8048671	0.239	0.018
MIR138-2	rs1529930	0.165	0.009		rs9921866	0.2	0.009
MKL2	rs4267326	0.264	0.008
The Health and Retirement Study
Gene ^a	SNPs ^b	Per allele change	Per allele change	Gene ^a	SNPs ^b	Per allele change	Per allele change
		in BMI by HBM	in BMI by MLM			in BMI by HBM	in BMI by MLM
CDH13	rs7199677	0.14	0.005	KIAA0513	rs8045387	0.112	0.001
CMIP	rs10514518	0.123	0.002	LOC102724927	rs2601773	0.112	0.002
FTO	rs9939609	0.143	0.003	MPHOSPH6	rs2303267	0.183	0.007
FTO	rs9940128	0.163	0.009	NDRG4	rs11076243	0.133	0.002
RBFOX1	rs11076998	0.162	0.004	PAPD5	rs7191151	0.129	0.003
RBFOX1	rs11647425	0.104	0.001	PSKH1	rs2136648	0.141	0.005
RBFOX1	rs12448747	0.173	0.004	RP11-488I20.3	rs13332284	0.202	0.011
RBFOX1	rs1473145	0.132	0.003	URAHP	rs9921920	0.121	0.008
RBFOX1	rs17562548	0.211	0.02	VAT1L	rs13330130	0.11	0.001
RBFOX1	rs1860304	0.174	0.006		rs11075417	0.147	0.003
SLC38A8	rs4782578	0.137	0.009		rs1362441	0.122	0.002
WWOX	rs16948787	0.111	0.004		rs154554	0.16	0.002
WWOX	rs4888855	0.223	0.019		rs16960867	0.151	0.005
BCAR1	rs4261573	0.118	0.001		rs4023915	0.155	0.006
CDH11	rs1520229	0.183	0.009		rs4467088	0.113	0.002
CLEC16A	rs767019	0.115	0.002		rs4784621	0.106	0.001
CMC2	rs2549855	0.111	0.002		rs7187990	0.104	0
CNGB1	rs7184838	0.172	0.012		rs8045580	0.126	0.005
CNTNAP4	rs4888514	0.178	0.008		rs964933	0.114	0.001
GPR139	rs868554	0.14	0.002		rs9925215	0.119	0.005

^aThe same genes are identified associated with BMI using both FHS and HRS data are shown in blue. ^bSNPs identified to be associated with BMI in both FHS and HRS data are shown in red.

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ISSN: 1471-2164

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