Molecular and cellular functions deregulated in breast cancer. Description: Functions are sized by -log (p-value), which shows the associated log of the calculated p-value. Larger squares indicate highly significant overlap between the genes perturbed in the dataset and the biological function or disease. The functions are colored by z-score. The color shows the direction of change for the function, based on the regulation z-score: The positive (orange) score denotes that the biological process or disease is trending towards an increase and the negative (blue) score denotes that the biological process or disease is trending towards a decrease.