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Table 2 Differentially expressed genes between BRAFwt and BRAFmut PTCs and TN samples

From: Effect of BRAFmutational status on expression profiles in conventional papillary thyroid carcinomas

Gene name Gene symbol BRAFwt PTC vs. BRAFmut PTC BRAFwt PTC vs. TN BRAFmut PTC vs. TN
   FC1 P FC1 P FC1 P 2
keratin 19 KRT19 -4.39 1.3E-09 2.37 2.0E-04 10.43 8.5E-13
potassium voltage-gated channel, shaker-related subfamily, beta member 1 KCNAB1 7.66 6.4E-09 3.23 5.5E-04 -2.37 5.7E-03
solute carrier family 26, member 4 SLC26A4 7.59 4.3E-08 2.14 2.9E-02 -3.55 4.0E-04
TBC1 domain family, member 2 TBC1D2 -2.39 4.4E-08 2.71 1.0E-07 6.48 3.3E-14
tumor protein D52-like 1 TPD52L1 -2.46 3.2E-07 2.22 3.6E-05 5.46 1.1E-11
TP53 apoptosis effector PERP -2.09 3.6E-07 2.97 6.9E-09 6.22 1.6E-14
Periplakin PPL -2.53 1.0E-06 2.92 1.9E-06 7.41 2.3E-12
growth differentiation factor 15 GDF15 -5.08 1.5E-06 2.41 1.1E-02 12.23 6.8E-09
deltex homolog 4 (Drosophila) DTX4 -3.31 3.5E-06 3.28 5.6E-05 10.86 8.4E-11
death-associated protein kinase 2 DAPK2 -2.45 1.0E-05 2.78 2.1E-05 6.83 7.6E-11
ethanolamine kinase 2 ETNK2 -2.51 1.9E-05 2.02 3.0E-03 5.07 1.3E-08
solute carrier family 34 (sodium phosphate), member 2 SLC34A2 -4.75 2.2E-05 8.86 2.2E-06 42.09 1.9E-11
transmembrane protein 98 TMEM98 -2.09 2.8E-05 2.24 9.8E-05 4.69 6.2E-10
gamma-glutamylcyclotransferase GGCT -2.52 3.1E-05 2.48 3.7E-04 6.26 2.3E-09
purine nucleoside phosphorylase PNP -3.55 3.4E-05 2.48 6.6E-03 8.82 4.7E-08
protein S (alpha) PROS1 -2.80 3.7E-05 5.78 1.4E-07 16.18 2.8E-12
FERM domain containing 4B FRMD4B 2.50 3.7E-05 5.04 7.3E-08 2.01 3.1E-03
mucin 1, cell surface associated MUC1 -2.29 5.6E-05 2.23 6.8E-04 5.12 6.6E-09
protein tyrosine phosphatase, receptor type, E PTPRE -2.22 6.0E-05 2.45 1.3E-04 5.43 1.5E-09
gamma-aminobutyric acid (GABA) A receptor, beta 2 GABRB2 -4.73 8.6E-05 2.82 1.7E-02 13.32 3.0E-07
metastasis associated in colon cancer 1 MACC1 -2.34 1.2E-04 2.15 2.3E-03 5.02 4.0E-08
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 CITED1 -3.58 3.4E-04 2.56 1.8E-02 9.17 1.1E-06
laminin, beta 3 LAMB3 -3.13 3.4E-04 2.46 1.2E-02 7.70 6.7E-07
syndecan 4 SDC4 -2.22 4.3E-04 4.25 1.6E-06 9.45 1.2E-10
family with sequence similarity 129, member A FAM129A -2.21 4.3E-04 2.27 1.9E-03 5.03 9.8E-08
fibronectin 1 FN1 -2.60 4.9E-04 10.31 8.2E-09 26.78 1.5E-12
phosphodiesterase 5A, cGMP-specific PDE5A -2.82 7.1E-04 6.06 6.7E-06 17.11 6.5E-10
dual specificity phosphatase 5 DUSP5 -2.11 7.9E-04 2.16 3.1E-03 4.57 2.8E-07
chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1 -4.45 8.5E-04 3.50 1.4E-02 15.59 1.8E-06
cathepsin H CTSH -2.63 9.2E-04 5.31 1.1E-05 13.97 1.2E-09
trefoil factor 3 (intestinal) TFF3 3.81 1.5E-05 -2.86 2.6E-02 -10.92 5.4E-06
met proto-oncogene (hepatocyte growth factor receptor) MET -2.27 2.7E-11 8.93 1.3E-08 20.25 4.6E-12
  1. 1FC, fold change; -, downregulated in BRAFwt PTCs vs. BRAFmut PTCs, downregulated in BRAFwt PTCs vs. TN, and downregulated in BRAFmut PTCs vs. TN; 2p-value with FDR < 0.05 and fold change cutoff > 2