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Table 1 Fifty-five genes differentially expressed between FVPTCs and FAs and comparison with TN sample expression

From: Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid

Gene name Gene symbol FVPTC vs. FA FVPTC vs. TN FA vs. TN
   FC1 P 2 FC1 P FC1 P
gamma-aminobutyric acid (GABA) B receptor, 2 GABBR2 7.09 1.06E-07 8.51 2.99E-08 1.20 4.10E-01
neuronal cell adhesion molecule NRCAM 4.09 1.64E-07 4.06 1.76E-07 -1.01 9.64E-01
extracellular matrix protein 1 ECM1 18.36 5.77E-07 15.49 1.28E-06 -1.19 6.44E-01
heparan sulfate 6-O-sulfotransferase 2 HS6ST2 5.07 8.60E-07 3.77 1.11E-05 -1.35 1.71E-01
retinoid X receptor, gamma RXRG 13.16 8.69E-07 15.64 3.64E-07 1.19 6.08E-01
insulin-like growth factor 2 mRNA binding protein 2 IGF2BP2 5.88 1.10E-06 4.90 4.45E-06 -1.20 4.40E-01
cellular retinoic acid binding protein 2 CRABP2 4.48 1.18E-06 4.20 2.07E-06 -1.07 7.50E-01
high mobility group AT-hook 2 HMGA2 5.15 1.33E-06 3.17 8.64E-05 -1.62 3.91E-02
interaction protein for cytohesin exchange factors 1 IPCEF1 -6.48 1.39E-06 -3.55 1.32E-04 1.82 2.70E-02
G protein-coupled receptor 155 GPR155 -2.83 2.09E-06 -1.31 8.64E-02 2.16 4.76E-05
Purkinje cell protein 4 PCP4 -2.47 2.17E-06 -1.50 5.96E-03 1.65 9.10E-04
dipeptidyl-peptidase 10 (non-functional) DPP10 3.85 2.22E-06 1.99 2.34E-03 -1.93 2.49E-03
low density lipoprotein receptor-related protein 4 LRP4 8.23 3.70E-06 13.56 2.22E-07 1.65 1.16E-01
chondroitin sulfate N-acetylgalactosaminyltransferase 1 CSGALNACT1 -3.34 4.06E-06 -1.13 5.01E-01 2.95 9.50E-06
fibronectin type III domain containing 4 FNDC4 3.65 5.75E-06 2.48 2.85E-04 -1.47 6.15E-02
leucine-rich repeat kinase 2 LRRK2 20.97 6.06E-06 31.24 1.27E-06 1.49 3.92E-01
odz, odd Oz/ten-m homolog 1 (Drosophila) ODZ1 13.95 6.87E-06 13.63 7.66E-06 -1.02 9.54E-01
lipase, member H LIPH 18.83 7.39E-06 20.52 5.19E-06 1.09 8.49E-01
glutamate receptor interacting protein 1 GRIP1 -2.52 7.61E-06 -1.24 1.66E-01 2.04 9.33E-05
slit homolog 1 (Drosophila) SLIT1 6.12 8.81E-06 9.01 7.51E-07 1.47 1.83E-01
protocadherin 7 PCDH7 3.46 8.83E-06 2.96 4.20E-05 -1.17 4.26E-01
proteolipid protein 1 PLP1 10.00 8.88E-06 4.92 4.63E-04 -2.03 6.14E-02
SOGA family member 3 SOGA3 2.54 9.38E-06 2.44 1.59E-05 -1.04 7.81E-01
patched domain containing 4 PTCHD4 9.30 1.03E-05 3.03 7.04E-03 -3.07 4.90E-03
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosamine GALNT7 3.57 1.04E-05 8.03 1.35E-08 2.25 7.59E-04
glutaminyl-peptide cyclotransferase QPCT 6.05 1.18E-05 5.68 1.79E-05 -1.06 8.27E-01
transcription factor CP2-like 1 TFCP2L1 -4.40 1.42E-05 -1.80 2.95E-02 2.45 1.51E-03
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) CWH43 -4.73 1.47E-05 -2.32 4.77E-03 2.04 1.10E-02
pleiomorphic adenoma gene 1 PLAG1 5.46 1.47E-05 3.88 1.75E-04 -1.41 2.26E-01
UDP-galactose-4-epimerase GALE 2.74 1.52E-05 2.39 8.06E-05 -1.15 4.04E-01
neurotrophic tyrosine kinase, receptor, type 3 NTRK3 3.64 1.75E-05 2.68 3.21E-04 -1.36 1.61E-01
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KIT -4.84 1.93E-05 -1.47 1.72E-01 3.30 2.53E-04
acid phosphatase, prostate ACPP 2.41 2.59E-0 2.48 1.72E-05 1.03 8.34E-01
diacylglycerol kinase, iota DGKI -3.53 3.16E-05 -1.88 1.19E-02 1.87 9.87E-03
vitamin D (1,25- dihydroxyvitamin D3) receptor VDR 2.62 3.26E-05 2.63 3.09E-05 1.00 9.79E-01
family with sequence similarity 70, member A FAM70A 2.74 3.30E-05 1.05 7.91E-01 -2.61 3.66E-05
uncharacterized LOC100129434 LOC100129434 -2.60 3.63E-05 -1.37 8.73E-02 1.90 1.22E-03
spermatogenesis associated 18 SPATA18 2.70 4.41E-05 1.95 1.93E-03 -1.38 8.18E-02
retrotransposon gag domain containing 4 RGAG4 3.13 4.80E-05 4.19 3.16E-06 1.34 1.66E-01
zinc finger protein 521 ZNF521 2.72 5.44E-05 4.00 1.03E-06 1.47 4.63E-02
pleckstrin and Sec7 domain containing 3 PSD3 3.50 5.69E-05 8.64 5.67E-08 2.47 9.62E-04
synapse differentiation inducing 1 SYNDIG1 -2.67 5.72E-05 -1.47 5.38E-02 1.82 3.60E-03
LIM domain only 3 (rhombotin-like 2) LMO3 2.66 5.86E-05 5.59 4.25E-08 2.10 6.13E-04
adhesion molecule with Ig-like domain 2 AMIGO2 2.87 5.90E-05 2.51 2.35E-04 -1.14 5.02E-01
RNA binding protein with multiple splicing 2 RBPMS2 -2.73 6.11E-05 1.01 9.51E-01 2.76 3.45E-05
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) ITGA2 2.72 6.37E-05 5.15 1.30E-07 1.89 2.75E-03
sodium channel, voltage-gated, type IV, alpha subunit SCN4A 2.29 6.51E-05 2.70 8.15E-06 1.18 2.95E-01
neuro-oncological ventral antigen 1 NOVA1 3.86 7.79E-05 2.49 2.83E-03 -1.55 9.88E-02
SMAD family member 9 SMAD9 -3.03 7.91E-05 -1.18 4.60E-01 2.57 2.66E-04
Sciellin SCEL 5.85 8.10E-05 6.23 5.50E-05 1.07 8.48E-01
SLC26A8 SLC26A8 2.71 8.28E-05 1.45 7.47E-02 -1.87 3.65E-03
serine-rich and transmembrane domain containing 1 SERTM1 -5.94 8.38E-05 -1.58 2.05E-01 3.76 9.96E-04
calpain 3 (p93) CAPN3 2.23 8.41E-05 2.93 2.60E-06 1.32 8.34E-02
immunoglobulin superfamily, member 1 IGSF1 8.63 8.51E-05 9.28 5.97E-05 1.07 8.60E-01
primary ciliary dyskinesia protein 1 PCDP1 -2.17 8.74E-05 -1.23 1.91E-01 1.77 1.15E-03
  1. 1FC, fold change;2p-value with FDR < 0.05 and fold change cutoff > 2; -, downregulated in FVPTCs vs. FAs, downregulated in FVPTCs vs. TN, and downregulated in FAs vs. TN.