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Figure 3 | BMC Genomics

Figure 3

From: Use of Both Cumulus Cells’ Transcriptomic Markers and Zona Pellucida Birefringence to Select Developmentally Competent Oocytes in Human Assisted Reproductive Technologies

Figure 3

Gene network of differentially expressed candidates in CCs involved in both cell morphology and intracellular signalling pathways cross-talk. (Red): overexpressed genes. (Green): underexpressed genes. (White): other genes. Overexpressed genes are PRDX2 (peroxiredoxin 2), HBA1/HBA2 (hemoglobin, alpha 1/ hemoglobin, alpha 2), HBB (hemoglobin, beta), RAN (RAN, member RAS oncogene family), CASP9 (caspase 9), HDAC2 (histone deacetylase 2), HSP90B1 (heat shock protein 90, beta, member 1), TIE1 (tyrosine kinase with immunoglobulin-like and EGF-like domains 1), GLB1 (galactosidase, beta 1), CDKN1A (cyclin-dependent kinase inhibitor 1A) and RGS3 (regulator of G-protein signaling 3). Underexpressed genes are CCNA2 (cyclin A2) and CYP11A1 (cytochrome P450, family 11, subfamily A, polypeptide 1). Other genes are ADRB (Adrenoreceptor, Beta), Ck2 (casein Kinase II), PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase), PKC (protein Kinase C), MAPK and ERK1/2 (mitogen-activated protein kinase family), HSP70 (heat shock protein 70), RNA polymerase II, Insulin, AP1 (activator protein-1), CD3 and LH (luteinizing hormone).

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