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Figure 4 | BMC Genomics

Figure 4

From: Use of Both Cumulus Cells’ Transcriptomic Markers and Zona Pellucida Birefringence to Select Developmentally Competent Oocytes in Human Assisted Reproductive Technologies

Figure 4

Gene network of several differentially expressed CCs genes involved in both apotosis and anti-inflammatory-like response. (Red): overexpressed genes. (Green): underexpressed genes. (White): other genes. Overexpressed genes are CCAR1 (cell division cycle and apoptosis regulator 1), RGS3 (regulator of G-protein signaling 3), PRDX2 (peroxiredoxin 2), HSP90 / HSP90B1 (heat shock protein 90, beta, member 1), PANX1 (pannexin 1), CASP9 (caspase 9), CDKN1A (cyclin-dependent kinase inhibitor 1A), PSIP1(PC4 and SFRS1 interacting protein 1), RAN (RAN, member RAS oncogene family) and HDAC / HDAC2 (histone deacetylase 2). Underexpressed genes are FOSB (FBJ murine osteosarcoma viral oncogene homolog B), FDPS (farnesyl diphosphate synthetase), TAX1BP1 (Tax1 (human T-cell leukemia virus type I) binding protein 1), HSPA8/ HSP70 (heat shock protein 70 kDa, protein 8), CCNA2 (cyclin A2) and ENO1 (Enolase 1, alpha). The other genes of the network are ERK1/2 (Extracellular signal-regulated kinase 1 /2, mitogen-activated protein kinase family), HSP27 (heat shock 27kDa protein), BCR (complex) (B-cell receptor complex), PP2A (protein phosphatase type 2a), Histone H1, PKG (protein kinase G), LDL (low density lipoprotein) and IL1 (interleukin 1).

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