Figure 4From: Use of Both Cumulus Cells’ Transcriptomic Markers and Zona Pellucida Birefringence to Select Developmentally Competent Oocytes in Human Assisted Reproductive TechnologiesGene network of several differentially expressed CCs genes involved in both apotosis and anti-inflammatory-like response. (Red): overexpressed genes. (Green): underexpressed genes. (White): other genes. Overexpressed genes are CCAR1 (cell division cycle and apoptosis regulator 1), RGS3 (regulator of G-protein signaling 3), PRDX2 (peroxiredoxin 2), HSP90 / HSP90B1 (heat shock protein 90, beta, member 1), PANX1 (pannexin 1), CASP9 (caspase 9), CDKN1A (cyclin-dependent kinase inhibitor 1A), PSIP1(PC4 and SFRS1 interacting protein 1), RAN (RAN, member RAS oncogene family) and HDAC / HDAC2 (histone deacetylase 2). Underexpressed genes are FOSB (FBJ murine osteosarcoma viral oncogene homolog B), FDPS (farnesyl diphosphate synthetase), TAX1BP1 (Tax1 (human T-cell leukemia virus type I) binding protein 1), HSPA8/ HSP70 (heat shock protein 70 kDa, protein 8), CCNA2 (cyclin A2) and ENO1 (Enolase 1, alpha). The other genes of the network are ERK1/2 (Extracellular signal-regulated kinase 1 /2, mitogen-activated protein kinase family), HSP27 (heat shock 27kDa protein), BCR (complex) (B-cell receptor complex), PP2A (protein phosphatase type 2a), Histone H1, PKG (protein kinase G), LDL (low density lipoprotein) and IL1 (interleukin 1).Back to article page