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Table 1 Main molecular, cellular and physiological functions triggered by CCs in ZGP versus ZGNP. These functions are ranked by p-value and their proportion of differentially expressed genes (both overexpressed and underexpressed) according to the IPA software.

From: Use of Both Cumulus Cells’ Transcriptomic Markers and Zona Pellucida Birefringence to Select Developmentally Competent Oocytes in Human Assisted Reproductive Technologies

Molecular, cellular and physiological functions

p-value

No. genes

Proportion of differentially expressed genes involved (%)*

Physiological functions / conditions

Reproductive and embryonic development

4.13E-05 - 2.95E-02

17

22.67

 

Organ morphology

5.92E-06 - 2.95E-02

16

21.33

 

Inflammatory-like response

2.86E-04 - 2.95E-02

14

18.67

Molecular & cellular functions

Cell Morphology

5.92E-06 - 2.95E-02

22

29.33

 

Small molecule biochemistry & signaling

1.09E-04 - 2.59E-02

13

17.33

 

Cellular assembly and organization

4.13E-05 - 2.95E-02

9

12.00

 

Cell cycle

1.37E-04 - 2.59E-02

5

6.67

  1. *: The proportion of differentially expressed genes included both over- and under-expressed genes