Figure 7

Evolutionary history of the adjacency between RCSD1 (turquoise) and CREG1 (light green). ARt-DeCo infers the creation of this adjacency at the root of Amniots. We integrated the different evolutionary events concerning the RCSD1-CREG1 adjacency along the species tree. Empty red crosses represents an adjacency losses (i.e., cases where both adjacent genes are lost at the same time); each full red cross represents a gene loss (only one of the genes is lost); each empty green square indicates an adjacency duplication (places where the two adjacent genes are duplicated together); a full green square indicates a gene duplication and an orange triangle represents an adjacency gain. Color code for species name gives information on adjacency status. In red species, RCSD1 and CREG1 genes are not adjacent, while blue species host the RCSD1-CREG1 adjacency as described by Ensembl, and green species have the RCSD1-CREG1 adjacency inferred by ARt-DeCo (though it is absent from Ensembl). For green species, the adjacency support is indicated. For some species, representing most of the clades in Ensembl, we illustrate the gene content around the RCSD1-CREG1 adjacency, which illustrates strong similarities in the genomes of blue and green species.