Figure 2
From: Widespread signatures of local mRNA folding structure selection in four Dengue virus serotypes
A. Profiles of MFE related signal conservation along the coding regions of 4 DENV serotypes for strong (red) and weak (green) folding. Positions with FSCI higher than a maximal value achieved in random (which is denoted by the shadowed area and is very similar for strong and weak folding) are not expected to be obtained by chance (p-value < 0.001 with respect to FSCI values based on randomized signals; Benjamini-Hochberg FDR = 0.001) and are defined as positions which may undergo a conserved selection for strong / weak local folding energy (shortly, MFE-selected). B. Distribution of FSCI values in MFE-selected positions for strong / weak folding in 4 serotypes. The maximal FSCI values achieved in random are explicitly annotated (rand FSCI) and marked by black vertical bars. Total number of MFE-selected positions in wild-type is 40-100 folds higher than in random.