TY - JOUR AU - Lee, Jong-Hun AU - Park, Sung-Joon AU - Kenta, Nakai PY - 2015 DA - 2015/12/09 TI - An integrative approach for efficient analysis of whole genome bisulfite sequencing data JO - BMC Genomics SP - S14 VL - 16 IS - 12 AB - Whole genome bisulfite sequencing (WGBS) is a high-throughput technique for profiling genome-wide DNA methylation at single nucleotide resolution. However, the applications of WGBS are limited by low accuracy resulting from bisulfite-induced damage on DNA fragments. Although many computer programs have been developed for accurate detecting, most of the programs have barely succeeded in improving either quantity or quality of the methylation results. To improve both, we attempted to develop a novel integration of most widely used bisulfite-read mappers: Bismark, BSMAP, and BS-seeker2. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-16-S12-S14 DO - 10.1186/1471-2164-16-S12-S14 ID - Lee2015 ER -