Figure 1
From: An integrative approach for efficient analysis of whole genome bisulfite sequencing data
Concept map and workflow of a research. (a) Concept map for integrative approach. (b) Workflow of analysis and integration. We generated methylated reads by Sherman and mapped those reads with three mappers; Bismark, BSMAP, and BS-seeker2. Based on the analysis of the three mappers, we integrated the mapping results of the three mappers with three methods; Ave, wAve, and pwAve. Lastly, we evaluated the performances of the integrations with respect to detection accuracy (d-accuracy) and detected amount of cytosine (d-amount). (c) The d-accuracy was calculated by 1-difference between generated and detected methylation level at each block.