Results with real WGBS data. (a) d-amount of WGBS samples. ESC=Embryonic stem cell, iPSC = induced pluripotent stem cell, Br = brain, d = day and y = year (e.g. Br-5 y means 5 years old brain). Hierarchical clustering results based on CpG (b) and CpH (c) methylation levels of 10 kbps blocks across samples. The distance is 1-spearman correlation coefficient. (d) Spearman correlation coefficients of CpH methylation between liver with brain from same experiment (Br-unknown) and with a brain from different experiment (Br-42 y).