Figure 1
From: An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer
Integrative bioinformatics research strategyto dissect kinase dependency in TNBC. The Kinase Addiction Ranker (KAR) algorithm integrates gene expression, drug screen, and quantitative kinase-drug binding data to predict kinase dependence in TNBC cell lines. The top ranking kinases by KAR are then queried by K-Map to predict effective compounds. These predictions are then validated experimentally or in literature.