KAR identifies relationships in kinase dependency in TNBC. A. Hierarchical clustering ofTNBC cell lines and kinases based on scaled kinase dependency scores. Each column was normalized to give a mean of 0 and a standard definition of 1. Red indicates that a cell line has a high dependence on a given kinase and blue indicates low dependence. Mutation and subtype information are also provided . B. Hierarchical clustering of TNBC cell lines based on kinase inhibitor sensitivity data (from ). Clustering based on kinase inhibitor sensitivity resulted in different groupings compared to kinase dependency score. Red indicates that a cell line has higher sensitivity to a particular kinase inhibitor (lower IC50) and blue indicates lower sensitivity (higher IC50).