Figure 3
From: An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer
Validation of bosutinib and erlotinib in TNBC cell line HCC1806. A. Cell viability (mean +/- SE) dose response for bosutinib and erlotinib in HCC1806. B. Estimation of the IC50 for bosutinib and erlotinib in HCC1806. HCC1806 was much more sensitive to bosutinib than erlotinib. While both compounds target EGFR (KAR rank = 3), bosutinib targets other top ranking kinases by KAR: YES1, TNK2, MAP4K4, and LYN.