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Table 1 Top 5 kinases ranked by KAR for the 12 TNBC lines.

From: An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer

TNBC Cell Line Top 5 Kinases (Score, p-value) ranked by KAR
(Number of significant kinases, p < 0.05) Rank 1 Rank 2 Rank 3 Rank 4 Rank 5
BT20 EGFR MAP4K2 MAP4K3 MAP3K9 MARK4
(9) (160, 0.0095) (150, 0.0095) (155, 0.016) (160, 0.0257) (90, 0.039)
BT549 MAP4K4 MINK1 MAP3K11 MAP4K5 NUAK1
(42) (115, 1.1 × 10-5) (80, 7.1 × 10-5) (95, 0.0001) (120, 0.0002) (110, 0.0002)
CAL148 MAP4K2 CDK5 / p25 CDK2 / cyclin A IRAK1 AURKB
(14) (75, 0.0029) (65, 0.0073) (60, 0.0073) (40, 0.0084) (95, 0.0108)
HCC38 MAP3K9 MAP4K5 MARK4 MAP4K4 MINK1
(43) (85, 1.79 × 10-5) (95, 5.73 × 10-5) (85, 5.73 × 10-5) (100, 8.05 × 10-5) (85, 9,47 × 10-5)
HCC70 PRKD3 CDK5 / p25 STK3 MAP3K9 AURKA
(24) (90, 0.0015) (100, 0.0031) (75, 0.0115) (65, 0.0127) (45, 0.0129)
HCC1143 CDK5 / p25 MST4 CDK1/cyclin A CDK3/cyclin E RAF1
(46) (45, 0.0005) (40, 0.0005) (30, 0.0041) (30, 0.0041) (10, 0.0041)
HCC1187 CLK4 ROCK2 PIK3CA GSK3B MAP3K9
(13) (60, 0.0182) (50, 0.0182) (45, 0.0182) (85, 0.0197) (85, 0.0229)
HCC1806 YES1 TNK2 EGFR MAP4K4 LYN
(23) (195, 0.0004) (180, 0.0004) (125, 0.0041) (170, 0.0058) (130, 0.0072)
HS578T PDGFRB MAP4K4 LYN MTOR CLK4
(22) (60, 0.0005) (50, 0.0022) (70, 0.0024) (60, 0.0024) (30, 0.0037)
MDA-MB-231 MAP3K7 CDK1 / cyclin A IGF1R CDK5 / p25 CDK6 / cyclin D1
(32) (40, 0.0007) (40, 0.0007) (25, 0.0007) (35, 0.0013) (25, 0.0039)
MDA-MB-468 CDK2 / cyclin A CDK5 / p25 MAP3K9 STK4 PRKD3
(10) (95, 0.0047) (95, 0.0047) (155, 0.0062) (155, 0.0062) (90, 0.0164)
MFM-223 ROCK2 CLK4 AURKA RET MAP3K9
(13) (50, 0.0043) (45, 0.0043) (35, 0.0043) (40, 0.0126) (25, 0.0171)