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Table 2 To 5 kinase inhibitors predicted by K-Map for the 12 TNBC lines.

From: An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer

 

Top 5 Drugs (Score) ranked by K-Map

TNBC Cell Line

Rank 1

Rank 2

Rank 3

Rank 4

Rank 5

BT20

Staurosporine

Bosutinib

Go 6976

TWS119

PKR Inhibitor

 

(1.00)

(0.976)

(0.972)

(0.963)

(0.953)

BT549

Staurosporine

K-252a

SB 218078

CDK1/2 Inhibitor III

Go 6976

 

(1.00)

(1.00)

(0.997)

(0.995)

(0.995)

CAL148

Lestaurtinib

K-252a

Staurosporine

JAK3 Inhibitor VI

CDK1/2 Inhibitor III

 

(1.00)

(1.00)

(1.00)

(0.996)

(0.994)

HCC38

Staurosporine

K-252a

CDK1/2 Inhibitor III

SB 218078

Go 6976

 

(1.00)

(1.00)

(0.995)

(0.991)

(0.989)

HCC70

Lestaurtinib

Staurosporine

CDK1/2 Inhibitor III

K-252a

SB 218078

 

(1.00)

(1.00)

(0.998)

(0.998)

(0.983)

HCC1143

JNK Inhibitor II

CDK4 Inhibitor III

CDK4 Inhibitor II

VEGFR Receptor Inhibitor II

CHK2 Inhibitor II

 

(0.977)

(0.943)

(0.938)

(0.936)

(0.929)

HCC1187

Staurosporine

CDK1/2 Inhibitor III

JAK3 Inhibitor VI

JNJ-7706621

PKR Inhibitor

 

(1.00)

(0.998)

(0.990)

(0.973)

(0.971)

HCC1806

Bosutinib

TWS119

Staurosporine

Dasatinib

WHI-P154

 

(1.00)

(0.990)

(0.98)

(0.966)

(0.956)

HS578T

Staurosporine

SU11652

K-252a

Sunitinib

Dorsomorphin

 

(1.00)

(0.992)

(0.986)

(0.984)

(0.982)

MDA-MB-231

CDK1/2 Inhibitor III

Indirubin Derivative E804

Sunitinib

Aminopurvalanol A

CDK2 Inhibitor IV

 

(1.00)

(0.975)

(0.956)

(0.949)

(0.94)

MDA-MB-468

Lestaurtinib

Staurosporine

CDK1/2 Inhibitor III

K-252a

JAK3 Inhibitor VI

 

(1.00)

(1.00)

(0.998)

(0.998)

(0.99)

MFM-223

Staurosporine

CDK1/2 Inhibitor III

K-252a

JAK3 Inhibitor VI

SYK Inhibitor

 

(1.00)

(1.00)

(0.99)

(0.974)

(0.972)