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Table 2 To 5 kinase inhibitors predicted by K-Map for the 12 TNBC lines.

From: An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer

  Top 5 Drugs (Score) ranked by K-Map
TNBC Cell Line Rank 1 Rank 2 Rank 3 Rank 4 Rank 5
BT20 Staurosporine Bosutinib Go 6976 TWS119 PKR Inhibitor
  (1.00) (0.976) (0.972) (0.963) (0.953)
BT549 Staurosporine K-252a SB 218078 CDK1/2 Inhibitor III Go 6976
  (1.00) (1.00) (0.997) (0.995) (0.995)
CAL148 Lestaurtinib K-252a Staurosporine JAK3 Inhibitor VI CDK1/2 Inhibitor III
  (1.00) (1.00) (1.00) (0.996) (0.994)
HCC38 Staurosporine K-252a CDK1/2 Inhibitor III SB 218078 Go 6976
  (1.00) (1.00) (0.995) (0.991) (0.989)
HCC70 Lestaurtinib Staurosporine CDK1/2 Inhibitor III K-252a SB 218078
  (1.00) (1.00) (0.998) (0.998) (0.983)
HCC1143 JNK Inhibitor II CDK4 Inhibitor III CDK4 Inhibitor II VEGFR Receptor Inhibitor II CHK2 Inhibitor II
  (0.977) (0.943) (0.938) (0.936) (0.929)
HCC1187 Staurosporine CDK1/2 Inhibitor III JAK3 Inhibitor VI JNJ-7706621 PKR Inhibitor
  (1.00) (0.998) (0.990) (0.973) (0.971)
HCC1806 Bosutinib TWS119 Staurosporine Dasatinib WHI-P154
  (1.00) (0.990) (0.98) (0.966) (0.956)
HS578T Staurosporine SU11652 K-252a Sunitinib Dorsomorphin
  (1.00) (0.992) (0.986) (0.984) (0.982)
MDA-MB-231 CDK1/2 Inhibitor III Indirubin Derivative E804 Sunitinib Aminopurvalanol A CDK2 Inhibitor IV
  (1.00) (0.975) (0.956) (0.949) (0.94)
MDA-MB-468 Lestaurtinib Staurosporine CDK1/2 Inhibitor III K-252a JAK3 Inhibitor VI
  (1.00) (1.00) (0.998) (0.998) (0.99)
MFM-223 Staurosporine CDK1/2 Inhibitor III K-252a JAK3 Inhibitor VI SYK Inhibitor
  (1.00) (1.00) (0.99) (0.974) (0.972)